Most of the approximately 67,000 students, faculty and staff have filled out a vaccine verification form.
Another 98 were denied but filed appeals.
MSU leaders have said that the university would offer few religious and medical exemptions.
The school issued a requirement in July for everyone expected on campus this fall to be vaccinated by the end of August.
The university received 4,339 requests for vaccine exemptions, of which 3,138 were approved and 224 were denied.