Both sides are in crucial need of three points on the road to Qatar, sitting outside the qualification spots after 10 games
Both sides currently sit outside the qualification spots for the 2022 World Cup, knowing they need to pick up crucial points on the road to Qatar 2022.
TV channel, live stream & how to watch
Ahead of the game, Goal has the details of how to watch on TV, stream online, team news and more.
The Copa America runners-up in 2021 travel to Santiago without a few key players, who were forced to stay at their clubs at home
Chile is hoping for its first win against Paraguay in six years when it hosts Eduardo Berizzo’s side in CONMEBOL World Cup qualifying.
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Chile has won just one of its World Cup qualifying games so far, leaving it nine points behind the automatic qualification places after 10 matches. Arturo Vidal missed the 2-0 defeat to Peru due to injury and is likely to be absent again for the clash with fellow strugglers Paraguay.
Predicted Chile starting XI: Bravo; Isla, Maripan, Medel, Vegas; Nunez, Aranguiz, Pulgar, Meneses; Brereton Diaz, Sanchez.