Linked to Death: Inflammation During Hospitalization COVID-19


The researchers found that elevated C-reactive protein (CRP) was associated with other indicators of the severity of COVID-19 hospitalization such as supplemental oxygen and intravenous dexamethasone. There was an association seen for elevated CRP with increased mortality risk after COVID-19 recovery. When CRP was split into high and low groups at the median, this effect persisted in unadjusted and adjusted analyses (hazard ratios, 1.60 and 1.61, respectively). Oral steroid prescriptions at discharge were associated with a reduced risk for death postdischarge (adjusted hazard ratio, 0.49).

Story Highlights

  • Arch G. Mainous III, Ph.D., from the University of Florida in Gainesville, and colleagues analyzed electronic health records for patients from Jan. 1, 2020, through Dec. 31, 2021, for COVID-19-positive hospitalized adults. A total of 1,207 patients were followed for 12 months post-COVID-19 to examine the association between systemic inflammation and 12-month mortality risk.